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October 5, 2015 - Revised 12.15.15

Vectra DA Coding and Billing Guidelines (CM00019, V3)

The MolDX Team has completed the Vectra DA assessment and determined that the test meets criteria for analytical and clinical validity, and clinical utility as a reasonable and necessary Medicare benefit. As per the conclusion of the clinical utility study, MolDX will reimburse Vectra DA tests performed for dates of service on and after 06/30/12. Based on the developer's recommendation, this test should be limited to two services per patient per year.

To report a Vectra DA service, please submit the following claim information:

  • For services prior to 01/01/2016: CPT code 81479 – unlisted molecular pathology procedure
  • Services 01/01/2016 and forward CPT code 81490 – Autoimmune (RA), analysis of 12 biomarkers
  • Enter assigned Z - Code™ Identifier in the comment/narrative field for the following claim field/types:
    • Loop 2300 NTE01 for Part A or Loop 2400 or SV101-7 field  for Part B
    • Form locator 80 for Part A or Box 19 for Part B paper claim
  • Select the appropriate diagnosis from the following list:
    • ICD-9-CM Codes:
      • 714.0 - rheumatoid arthritis
      • 714.1 - Felty's syndrome
      • 714.2 - other RA with visceral or systemic involvement
      • 714.81 - rheumatoid lung
    • ICD-10-CM Codes:
      • M05.011 - Felty's syndrome, right shoulder
      • M05.012 - Felty's syndrome, left shoulder
      • M05.021 - Felty's syndrome, right elbow
      • M05.022 - Felty's syndrome, left elbow
      • M05.031 - Felty's syndrome, right wrist
      • M05.032 - Felty's syndrome, left wrist
      • M05.041 - Felty's syndrome, right hand
      • M05.042 - Felty's syndrome, left hand
      • M05.051 - Felty's syndrome, right hip
      • M05.052 - Felty's syndrome, left hip
      • M05.061 - Felty's syndrome, right knee
      • M05.062 - Felty's syndrome, left knee
      • M05.071 - Felty's syndrome, right ankle and foot
      • M05.072 - Felty's syndrome, left ankle and foot
      • M05.09 - Felty's syndrome, multiple sites
      • M05.111 - Rheumatoid lung disease with rheumatoid arthritis of right shoulder
      • M05.112 - Rheumatoid lung disease with rheumatoid arthritis of left shoulder
      • M05.121 - Rheumatoid lung disease with rheumatoid arthritis of right elbow
      • M05.122 - Rheumatoid lung disease with rheumatoid arthritis of left elbow
      • M05.131 - Rheumatoid lung disease with rheumatoid arthritis of right wrist
      • M05.132 - Rheumatoid lung disease with rheumatoid arthritis of left wrist
      • M05.141 - Rheumatoid lung disease with rheumatoid arthritis of right hand
      • M05.142 - Rheumatoid lung disease with rheumatoid arthritis of left hand
      • M05.151 - Rheumatoid lung disease with rheumatoid arthritis of right hip
      • M05.152 - Rheumatoid lung disease with rheumatoid arthritis of left hip
      • M05.161 - Rheumatoid lung disease with rheumatoid arthritis of right knee
      • M05.162 - Rheumatoid lung disease with rheumatoid arthritis of left knee
      • M05.171 - Rheumatoid lung disease with rheumatoid arthritis of right ankle and foot
      • M05.172 - Rheumatoid lung disease with rheumatoid arthritis of left ankle and foot
      • M05.19 - Rheumatoid lung disease with rheumatoid arthritis of multiple sites
      • M05.211 - Rheumatoid vasculitis with rheumatoid arthritis of right shoulder
      • M05.212 - Rheumatoid vasculitis with rheumatoid arthritis of left shoulder
      • M05.221 - Rheumatoid vasculitis with rheumatoid arthritis of right elbow
      • M05.222 - Rheumatoid vasculitis with rheumatoid arthritis of left elbow
      • M05.231 - Rheumatoid vasculitis with rheumatoid arthritis of right wrist
      • M05.232 - Rheumatoid vasculitis with rheumatoid arthritis of left wrist
      • M05.241 - Rheumatoid vasculitis with rheumatoid arthritis of right hand
      • M05.242 - Rheumatoid vasculitis with rheumatoid arthritis of left hand
      • M05.251 - Rheumatoid vasculitis with rheumatoid arthritis of right hip
      • M05.252 - Rheumatoid vasculitis with rheumatoid arthritis of left hip
      • M05.261 - Rheumatoid vasculitis with rheumatoid arthritis of right knee
      • M05.262 - Rheumatoid vasculitis with rheumatoid arthritis of left knee
      • M05.271 - Rheumatoid vasculitis with rheumatoid arthritis of right ankle and foot
      • M05.272 - Rheumatoid vasculitis with rheumatoid arthritis of left ankle and foot
      • M05.29 - Rheumatoid vasculitis with rheumatoid arthritis of multiple sites
      • M05.311 - Rheumatoid heart disease with rheumatoid arthritis of right shoulder
      • M05.312 - Rheumatoid heart disease with rheumatoid arthritis of left shoulder
      • M05.321 - Rheumatoid heart disease with rheumatoid arthritis of right elbow
      • M05.322 - Rheumatoid heart disease with rheumatoid arthritis of left elbow
      • M05.331 - Rheumatoid heart disease with rheumatoid arthritis of right wrist
      • M05.332 - Rheumatoid heart disease with rheumatoid arthritis of left wrist
      • M05.341 - Rheumatoid heart disease with rheumatoid arthritis of right hand
      • M05.342 - Rheumatoid heart disease with rheumatoid arthritis of left hand
      • M05.351 - Rheumatoid heart disease with rheumatoid arthritis of right hip
      • M05.352 - Rheumatoid heart disease with rheumatoid arthritis of left hip
      • M05.361 - Rheumatoid heart disease with rheumatoid arthritis of right knee
      • M05.362 - Rheumatoid heart disease with rheumatoid arthritis of left knee
      • M05.371 - Rheumatoid heart disease with rheumatoid arthritis of right ankle and foot
      • M05.372 - Rheumatoid heart disease with rheumatoid arthritis of left ankle and foot
      • M05.39 - Rheumatoid heart disease with rheumatoid arthritis of multiple sites
      • M05.411 - Rheumatoid myopathy with rheumatoid arthritis of right shoulder
      • M05.412 - Rheumatoid myopathy with rheumatoid arthritis of left shoulder
      • M05.421 - Rheumatoid myopathy with rheumatoid arthritis of right elbow
      • M05.422 - Rheumatoid myopathy with rheumatoid arthritis of left elbow
      • M05.431 - Rheumatoid myopathy with rheumatoid arthritis of right wrist
      • M05.432 - Rheumatoid myopathy with rheumatoid arthritis of left wrist
      • M05.441 - Rheumatoid myopathy with rheumatoid arthritis of right hand
      • M05.442 - Rheumatoid myopathy with rheumatoid arthritis of left hand
      • M05.451 - Rheumatoid myopathy with rheumatoid arthritis of right hip
      • M05.452 - Rheumatoid myopathy with rheumatoid arthritis of left hip
      • M05.461 - Rheumatoid myopathy with rheumatoid arthritis of right knee
      • M05.462 - Rheumatoid myopathy with rheumatoid arthritis of left knee
      • M05.471 - Rheumatoid myopathy with rheumatoid arthritis of right ankle and foot
      • M05.472 - Rheumatoid myopathy with rheumatoid arthritis of left ankle and foot
      • M05.49 - Rheumatoid myopathy with rheumatoid arthritis of multiple sites
      • M05.511 - Rheumatoid polyneuropathy with rheumatoid arthritis of right shoulder
      • M05.512 - Rheumatoid polyneuropathy with rheumatoid arthritis of left shoulder
      • M05.521 - Rheumatoid polyneuropathy with rheumatoid arthritis of right elbow
      • M05.522 - Rheumatoid polyneuropathy with rheumatoid arthritis of left elbow
      • M05.531 - Rheumatoid polyneuropathy with rheumatoid arthritis of right wrist
      • M05.532 - Rheumatoid polyneuropathy with rheumatoid arthritis of left wrist
      • M05.541 - Rheumatoid polyneuropathy with rheumatoid arthritis of right hand
      • M05.542 - Rheumatoid polyneuropathy with rheumatoid arthritis of left hand
      • M05.551 - Rheumatoid polyneuropathy with rheumatoid arthritis of right hip
      • M05.552 - Rheumatoid polyneuropathy with rheumatoid arthritis of left hip
      • M05.561 - Rheumatoid polyneuropathy with rheumatoid arthritis of right knee
      • M05.562 - Rheumatoid polyneuropathy with rheumatoid arthritis of left knee
      • M05.571 - Rheumatoid polyneuropathy with rheumatoid arthritis of right ankle and foot
      • M05.572 - Rheumatoid polyneuropathy with rheumatoid arthritis of left ankle and foot
      • M05.59 - Rheumatoid polyneuropathy with rheumatoid arthritis of multiple sites
      • M05.611 - Rheumatoid arthritis of right shoulder with involvement of other organs and systems
      • M05.612 - Rheumatoid arthritis of left shoulder with involvement of other organs and systems
      • M05.621 - Rheumatoid arthritis of right elbow with involvement of other organs and systems
      • M05.622 - Rheumatoid arthritis of left elbow with involvement of other organs and systems
      • M05.631 - Rheumatoid arthritis of right wrist with involvement of other organs and systems
      • M05.632 - Rheumatoid arthritis of left wrist with involvement of other organs and systems
      • M05.641 - Rheumatoid arthritis of right hand with involvement of other organs and systems
      • M05.642 - Rheumatoid arthritis of left hand with involvement of other organs and systems
      • M05.651 - Rheumatoid arthritis of right hip with involvement of other organs and systems
      • M05.652 - Rheumatoid arthritis of left hip with involvement of other organs and systems
      • M05.661 - Rheumatoid arthritis of right knee with involvement of other organs and systems
      • M05.662 - Rheumatoid arthritis of left knee with involvement of other organs and systems
      • M05.671 - Rheumatoid arthritis of right ankle and foot with involvement of other organs and systems
      • M05.672 - Rheumatoid arthritis of left ankle and foot with involvement of other organs and systems
      • M05.69 - Rheumatoid arthritis of multiple sites with involvement of other organs and systems
      • M05.711 - Rheumatoid arthritis with rheumatoid factor of right shoulder without organ or systems involvement
      • M05.712 - Rheumatoid arthritis with rheumatoid factor of left shoulder without organ or systems involvement
      • M05.721 - Rheumatoid arthritis with rheumatoid factor of right elbow without organ or systems involvement
      • M05.722 - Rheumatoid arthritis with rheumatoid factor of left elbow without organ or systems involvement
      • M05.731 - Rheumatoid arthritis with rheumatoid factor of right wrist without organ or systems involvement
      • M05.732 - Rheumatoid arthritis with rheumatoid factor of left wrist without organ or systems involvement
      • M05.741 - Rheumatoid arthritis with rheumatoid factor of right hand without organ or systems involvement
      • M05.742 - Rheumatoid arthritis with rheumatoid factor of left hand without organ or systems involvement
      • M05.751 - Rheumatoid arthritis with rheumatoid factor of right hip without organ or systems involvement
      • M05.752 - Rheumatoid arthritis with rheumatoid factor of left hip without organ or systems involvement
      • M05.761 - Rheumatoid arthritis with rheumatoid factor of right knee without organ or systems involvement
      • M05.762 - Rheumatoid arthritis with rheumatoid factor of left knee without organ or systems involvement
      • M05.771 - Rheumatoid arthritis with rheumatoid factor of right ankle and foot without organ or systems involvement
      • M05.772 - Rheumatoid arthritis with rheumatoid factor of left ankle and foot without organ or systems involvement
      • M05.79 - Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement
      • M05.811 - Other rheumatoid arthritis with rheumatoid factor of right shoulder
      • M05.812 - Other rheumatoid arthritis with rheumatoid factor of left shoulder
      • M05.821 - Other rheumatoid arthritis with rheumatoid factor of right elbow
      • M05.822 - Other rheumatoid arthritis with rheumatoid factor of left elbow
      • M05.831 - Other rheumatoid arthritis with rheumatoid factor of right wrist
      • M05.832 - Other rheumatoid arthritis with rheumatoid factor of left wrist
      • M05.841 - Other rheumatoid arthritis with rheumatoid factor of right hand
      • M05.842 - Other rheumatoid arthritis with rheumatoid factor of left hand
      • M05.851 - Other rheumatoid arthritis with rheumatoid factor of right hip
      • M05.852 - Other rheumatoid arthritis with rheumatoid factor of left hip
      • M05.861 - Other rheumatoid arthritis with rheumatoid factor of right knee
      • M05.862 - Other rheumatoid arthritis with rheumatoid factor of left knee
      • M05.871 - Other rheumatoid arthritis with rheumatoid factor of right ankle and foot
      • M05.872 - Other rheumatoid arthritis with rheumatoid factor of left ankle and foot
      • M05.89 - Other rheumatoid arthritis with rheumatoid factor of multiple sites
      • M06.011 - Rheumatoid arthritis without rheumatoid factor, right shoulder
      • M06.012 - Rheumatoid arthritis without rheumatoid factor, left shoulder
      • M06.021 - Rheumatoid arthritis without rheumatoid factor, right elbow
      • M06.022 - Rheumatoid arthritis without rheumatoid factor, left elbow
      • M06.031 - Rheumatoid arthritis without rheumatoid factor, right wrist
      • M06.032 - Rheumatoid arthritis without rheumatoid factor, left wrist
      • M06.041 - Rheumatoid arthritis without rheumatoid factor, right hand
      • M06.042 - Rheumatoid arthritis without rheumatoid factor, left hand
      • M06.051 - Rheumatoid arthritis without rheumatoid factor, right hip
      • M06.052 - Rheumatoid arthritis without rheumatoid factor, left hip
      • M06.061 - Rheumatoid arthritis without rheumatoid factor, right knee
      • M06.062 - Rheumatoid arthritis without rheumatoid factor, left knee
      • M06.071 - Rheumatoid arthritis without rheumatoid factor, right ankle and foot
      • M06.072 - Rheumatoid arthritis without rheumatoid factor, left ankle and foot
      • M06.08 - Rheumatoid arthritis without rheumatoid factor, vertebrae
      • M06.09 - Rheumatoid arthritis without rheumatoid factor, multiple sites
      • M06.1 - Adult - onset Still's disease
      • M06.211 - Rheumatoid bursitis, right shoulder
      • M06.212 - Rheumatoid bursitis, left shoulder
      • M06.221 - Rheumatoid bursitis, right elbow
      • M06.222 - Rheumatoid bursitis, left elbow
      • M06.231 - Rheumatoid bursitis, right wrist
      • M06.232 - Rheumatoid bursitis, left wrist
      • M06.241 - Rheumatoid bursitis, right hand
      • M06.242 - Rheumatoid bursitis, left hand
      • M06.251 - Rheumatoid bursitis, right hip
      • M06.252 - Rheumatoid bursitis, left hip
      • M06.261 - Rheumatoid bursitis, right knee
      • M06.262 - Rheumatoid bursitis, left knee
      • M06.271 - Rheumatoid bursitis, right ankle and foot
      • M06.272 - Rheumatoid bursitis, left ankle and foot
      • M06.28 - Rheumatoid bursitis, vertebrae
      • M06.29 - Rheumatoid bursitis, multiple sites
      • M06.311 - Rheumatoid nodule, right shoulder
      • M06.312 - Rheumatoid nodule, left shoulder
      • M06.321 - Rheumatoid nodule, right elbow
      • M06.322 - Rheumatoid nodule, left elbow
      • M06.331 - Rheumatoid nodule, right wrist
      • M06.332 - Rheumatoid nodule, left wrist
      • M06.341 - Rheumatoid nodule, right hand
      • M06.342 - Rheumatoid nodule, left hand
      • M06.351 - Rheumatoid nodule, right hip
      • M06.352 - Rheumatoid nodule, left hip
      • M06.361 - Rheumatoid nodule, right knee
      • M06.362 - Rheumatoid nodule, left knee
      • M06.371 - Rheumatoid nodule, right ankle and foot
      • M06.372 - Rheumatoid nodule, left ankle and foot
      • M06.38 - Rheumatoid nodule, vertebrae
      • M06.39 - Rheumatoid nodule, multiple sites
      • M06.811 - Other specified rheumatoid arthritis, right shoulder
      • M06.812 - Other specified rheumatoid arthritis, left shoulder
      • M06.821 - Other specified rheumatoid arthritis, right elbow
      • M06.822 - Other specified rheumatoid arthritis, left elbow
      • M06.831 - Other specified rheumatoid arthritis, right wrist
      • M06.832 - Other specified rheumatoid arthritis, left wrist
      • M06.841 - Other specified rheumatoid arthritis, right hand
      • M06.842 - Other specified rheumatoid arthritis, left hand
      • M06.851 - Other specified rheumatoid arthritis, right hip
      • M06.852 - Other specified rheumatoid arthritis, left hip
      • M06.861 - Other specified rheumatoid arthritis, right knee
      • M06.862 - Other specified rheumatoid arthritis, left knee
      • M06.871 - Other specified rheumatoid arthritis, right ankle and foot
      • M06.872 - Other specified rheumatoid arthritis, left ankle and foot
      • M06.88 - Other specified rheumatoid arthritis, vertebrae
      • M06.89 - Other specified rheumatoid arthritis, multiple sites

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